　 ■N. Osumi

　 ■ F.Suto

　N. Osumi－２００７

　　　■　Original paper

1) Osumi-Yamashita,N., Noji S., Nohno T., Koyama E., Doi H., Eto K. and Taniguchi S. Expression of retinoic acid receptor genes in the neural crest-derived cells during mouse facial development. FEBS letters 264, 71-74, 1990.

2) Tsuchiya, T., Takahashi, A., Asada, S., Takakubo, F., Osumi-Yamashita,N. and Eto, K. Comparative studies of embryotoxic action of ethlenethiourea in rat whole embryo and embryonic cell culture. Teratology 43, 319-324, 1991.

3) Osumi-Yamashita,N., Asada., S. and Eto., K.:Distribution of F-actin during mouse facial morphogenesis and its perturbation with cytochalasin D using whole embryo culture. J. Craniofac. Genet. Develop. Biol. 12, 130-140, 1992.

4) Osumi-Yamashita,N., Iseki, S., Noji, S., Nohno, T., Koyama, E., Taniguchi, S., Doi, H. and Eto, K.:Retinoic acid treatment induces the ectopic expression of retinoic acid receptor beta gene and excessive cell death in the embryonic mouse face. Develop. Growth & Differ. 34, 199-209, 1992.

5) Gui, T., Osumi-Yamashita,N., and Eto, K. Proliferation of nasal epithelial and mesenchymal cells during primary palate formation. J. Craniofac. Genet. Dev. Biol. 13, 250-258, 1993.

6) Matsuo, T., Osumi-Yamashita,N., Noji, S., Ohuchi, H., Koyama, E., Myokai, F., Matsuo, N., Taniguchi, S., Doi, H., Iseki, S., Ninomiya, Y., Fujiwara, M., Watnabe, T., and Eto, K. A mutation of the Pax-6 gene in rat "small eye" was associated with migration defect of midbrain crest cells. Nature Genet. 3, 299-304, 1993.

7) Yasui, K., Ninomiya, Y., Osumi-Yamashita,N., Shibanai, S. and Eto, K. Apical cell escape from the neuroepithelium and cell transformation during terminal lip fusion in the house shrew embryo. Anat. Embryol. 189, 463-473, 1994.

8) Motoyama, J., Taki, K., Osumi-Yamashita,N., and Eto, K. Retinoic acid treatment induces cell death and the protein expression of retinoic acid receptor beta in the mesenchymal cells of mouse facial primordia in vitro. Develop. Growth Differ. 36, 281-288, 1994.

9) Fujiwara, M., Uchida, T., Osumi-Yamashita,N. and Eto, K. Uchida rat (rSey): a new mutant rat with craniofacial abnormalities resembling those of the mouse Sey mutant. Differentiation 57, 31-38, 1994.

10) Osumi-Yamashita,N., Ninomiya, Y., Doi, H. and Eto, K. The contribution of both forebrain and midbrain crest cells to the mesenchyme in the frontonasal mass of mouse embryos. Develop. Biol. 164, 409-419, 1994.

11) Lee, Y.M., Osumi-Yamashita,N., Ninomiya, Y., Moon, C.K., Eriksson, U. and Eto, K.: Retinoic acid stage-dependently alters the migration pattern and identity of hindbrain neural crest cells. Development 121, 825-837, 1995.

12) Iseki, S., Osumi-Yamashita,N., Miyazono, K., Franzen, P., Ichijo, H., Ohtani, H., Hayashi, Y., and Eto, K.: Localization of transforming growth factor-beta type I and type II receptors in mouse development. Exp. Cell Res. 219, 339-347, 1995.

13) Aoki, K., Osumi-Yamashita,N., Ninomiya, Y., and Eto, K.: Differential expression of N-CAM, vimentin and MAP1B during initial pathfinding of olfactory receptor neurons in the mouse embryo. Anat. Embryol.192, 211-220, 1995.

14) Osumi-Yamashita,N., Ninomiya, Y., Doi, H. and Eto, K.: Rhombomere formation and hindbrain crest cell migration from prorhombomeric origins in mouse embryos. Develop. Growth Differ. 38, 107-118, 1996.

15) Imai, H., Osumi-Yamashita,N., Ninomiya, Y., and Eto, K.: Contribution of early-emigrating midbrain crest cells to the dental mesenchyme of the mandibular molar tooth in rat embryos. Develop. Biol. 176, 151-165, 1996.

16) Osumi-Yamashita,N., Kuratani, S., Ninomiya, Y., Aoki, K., Iseki, S., Chareonvit, S., Doi, H., Fujiwara, M., Watanabe, T. and Eto, K.: Cranial anomaly of homozygous rSey rat is associated with a defect in the migration pathway of midbrain crest cells. Devel. Growth & Differ. 39(1), 53-67, 1997.

17) Chareonvit, S., Osumi-Yamashita,N., Ikeda, M., and Eto, K.: Murine forebrain and midbrain crest cells generate different characteristic derivatives in vitro. Develop. Growth Differ., 39, 493-503, 1997.

18) Osumi,N., Hirota, A., Ohuchi, H., Nakafuku, M., Iimura, T., Kuratani, S., Fujiwara, M., Noji, S. and Eto, K.: Pax-6 is involved in specification of the hindbrain motor neuron subtype. Development 124, 2961-2972, 1997.

19) Imai, H., Osumi,N., and Eto, K.: Contribution of foregut endoderm to tooth initiation of mandibular incisor in rat embryos. Eur. J. Oral Sci. 106 (Supple 1), 19-23, 1998.

20) Kurisaki T, Masuda A, Osumi,N, Nabeshima Y, and Fujisawa-Sehara A. Spatially- and temporally-restricted expression of meltrin alpha (ADAM12) and beta (ADAM19) in mouse embryo. Mech Dev 73, 211-215, 1998.

21) Torii, M., Matsuzaki, F., Osumi,N,. Kaibuchi, K., Nakamura, S., Casarosa, S., Guillemot, F., and Nakafuku, M.: Transcription factors Mash-1 and Prox-1 delineate early steps in differentiation of neural stem cells in the developing central nervous system. Development 126, 443-456, 1999.

22) Kawano, H., Fukuda, T., Kubo, K., Horie, M., Takeuchi, K., Osumi,N., Eto, K., and Kawamura, K.: Pax6 is required for the thalamocortical pathway formation in fetal rats. J. Comp. Neurol. 408, 147-60, 1999.

23) Kamitori, S., machide, M., Osumi,N. and Kohsaka, S.: Expression of receptor tyrosine kinase RYK in developing rat central nervous system. Dev. Brain Res. 114, 149-160, 1999.

24) Shimoda Y., Tajima Y., Nagase T.,Harii K., Osumi,N., and Sanai Y. : Cloning and expression of a novel galactoside b1, 3--glucuronyltransferase involved in the biosynthesis of HNK-1 epitope. J. Biol. Chem. 274, 17115-17122, 1999.

25) Akamatsu W., Okano H.J., Osumi,N., Inoue T., Nakamura S., Sakakibara S., Miura M., Matsuo N., Darnell R.B. and Okano H. : Mammalian ELAV-like neuronal RNA-binding proteins HuB and HuC promote neuronal development in both the central and the peripheral nervous systems. Proc Natl Acad Sci U S A. 96(17):9885-90, 1999.

26) Ishii, Y., Nakamura, S. and Osumi, N.: Demarcation of early mammalian cortical development by differential expression of fringe genes. Brain Res Dev Brain Res 2000 Feb 7;119(2):307-320.

27) Inoue, T., Nakamura, S. and Osumi, N.: Fate mapping of the mouse prosencephalic neural plate. Dev Biol 2000 Mar 15;219(2):373-383.

28) Tetsuya Fukuda, Hitoshi Kawano, Noriko Osumi, Kazuhiro Eto, Koki Kawamura. Histogenesis of the cerebral cortex in rat fetuses with a mutation in the Pax-6 gene. Dev. Brain Res. Brain Res Dev Brain Res 2000 Mar 15;120(1):65-75.

29) Tomioka N, Osumi N, Sato Y, Inoue T, Nakamura S, Fujisawa H, Hirata T; Neocortical Origin and Tangential Migration of Guidepost Neurons in the Lateral Olfactory Tract. J Neurosci 2000 Aug 1;20(15):5802-5812.

30) Yamamoto H, Ochiya T, Takahama Y, Ishii Y, Osumi N, Sakamoto H, Terada M. Detection of spatial localization of Hst-1/Fgf-4 gene expression in brain and testis from adult mice.
Oncogene. 2000 Aug 3;19(33):3805-10.

31) Suzuki R, Shintani T, Sakuta H, Kato A, Ohkawara T, Osumi N, Noda M.I Identification of RALDH-3, a novel retinaldehyde dehydrogenase, expressed in the ventral region of the retina.
Mech Dev. 2000 Nov;98(1-2):37-50.

32) Nagase T, Shimoda Y, Sanai Y, Nakamura S, Harii K, Osumi N. Differential expression of two glucuronyltransferases synthesizing HNK-1 carbohydrate epitope in the sublineages of the rat myogenic progenitors. Mech Dev. 2000 Nov;98(1-2):145-9.

33) Inoue, T., Tanaka, T., Takeichi, M., Chisaka, O., Nakamura, S. and Osumi, N. (2001). Role of cadherins in maintaining the compartment boundary between the cortex and striatum during development. Development 128, 561-569.

34) T Yamasaki, K Kawaji, K Ono, H Bito, T Hirano, N Osumi, and M Kengaku. Pax6 regulates granule cell polarization during parallel fiber formation in the developing cerebellum Development 2001 128: 3133-3144

35) Nagase T, Nakamura S, Harii K, Osumi N.
Ectopically localized HNK-1 epitope perturbs migration of the midbrain neural crest cells in Pax6 mutant rat. Dev Growth Differ. 2001 Dec;43(6):683-692.

36) Shimoda Y, Tajima Y, Osanai T, Katsume A, Kohara M, Kudo T, Narimatsu H, Takashima N, Ishii Y, Nakamura S, Osumi N, Sanai Y. Pax6 controls the expression of Lewis x epitope in the embryonic forebrain by regulating alpha1,3-fucosyltransferase IX expression. J Biol Chem. 2002 Jan 18;277(3):2033-9.

37) Endo,Y., Osumi,N. and Wakamatsu, Y. Bimodal functions of Notch-mediated signaling are involved in neural crest formation during avian ectoderm development. Development 2002 129: 863-873.

38) Takahashi, M and Osumi, N. Pax6 regulates specification of ventral neurone subtypes in the hindbarin by establishing projenitor domains. Development 2002 129: 1327-1338.

39) Tatsumi Hirata, Tadashi Nomura, Yoshiko Takagi, Yasufumi Sato, Naomi Tomioka, Hajime Fujisawa and Noriko Osumi Mosaic development of the olfactory cortex with Pax6-dependent and -independent components Brain Res Dev Brain Res. 2002 136(1):17-26.

40) Ohsaki K, Osumi N, Nakamura S. Altered whisker patterns induced by ectopic expression of Shh are topographically represented by barrels. Brain Res Dev Brain Res. 2002 Aug 30;137(2):159.

41) Sakamaki K, Inoue T, Asano M, Sudo K, Kazama H, Sakagami J, Sakata S, Ozaki M, Nakamura S, Toyokuni S, Osumi N, Iwakura Y, Yonehara S. Ex vivo whole-embryo culture of caspase-8-deficient embryos normalize their aberrant phenotypes in the developing neural tube and heart.
Cell Death Differ. 2002 Nov;9(11):1196-206.

42) Horie M, Sango K, Takeuchi K, Honma S, Osumi N, Kawamura K, Kawano H. Subpial neuronal migration in the medulla oblongata of Pax-6-deficient rats. Eur J Neurosci. 2003 Jan;17(1):49-57.
.
43) Ryuichi Yamada, Yoko Mizutani-Koseki, Takanori Hasegawa, Noriko Osumi, Haruhiko Koseki, and Naoki Takahashi. Cell-autonomous involvement of Mab21l1 is essential for lens placode development. Development 2003 130: 1759-1770.

44) Fujino M, Osumi N, Ninomiya Y, Iseki S, Shibasaki Y, Eto K. Disappearance of epidermal growth factor receptor is essential in the fusion of the nasal epithelium. Anat Sci Int. 2003 Mar;78(1):25-35.

45) Endo,Y., Osumi, N, Wakamatsu, Y. Deltex/Dtx mediates NOTCH signaling in regulating Bmp4 expression for cranial neural crest formation during avian development. Dev Growth Differ. 2003 Jun;45(3):241-248.

46) Nagase T, Sanai Y, Nakamura S, Asato H, Harii K, Osumi N. Roles of HNK-1 carbohydrate epitope and its synthetic glucuronyltransferase genes on migration of rat neural crest cells. J Anat. 2003 Jul;203(1):77-88.

47) Kasai K, Takahashi M, Osumi N, Sinnarajah S, Takeo T, Ikeda H, Kehrl JH, Itoh G, Arnheiter H.The G12 family of heterotrimeric G proteins and Rho GTPase mediate Sonic hedgehog signalling. Genes Cells. 2004 Jan;9(1):49-58.

48) Wakamatsu Y, Endo Y, Osumi N, Weston JA. Multiple roles of Sox2, an HMG-box transcription factor in avian neural crest development. Dev Dyn. 2004 Jan;229(1):74-86.

49) Nomura T, Osumi N. Misrouting of mitral cell progenitors in the Pax6/small eye rat telencephalon.　Development 2004 131(4):787-796.

50) Wakamatsu Y, Osumi N, Weston JA.　Expression of a novel secreted factor, Seraf indicates an early segregation of Schwann cell precursors from neural crest during avian development.　Dev Biol. 2004 Apr 15;268(1):162-73.

51) Kobayashi K, Takahashi M, Matsushita N, Miyazaki JI, Koike M, Yaginuma H, Osumi N, Kaibuchi K, Kobayashi K. Survival of Developing Motor Neurons Mediated by Rho GTPase Signaling Pathway through Rho-Kinase. J Neurosci. 2004 Apr 7;24(14):3480-3488.

52) Takahashi M and Osumi N. Identification of a novel type II classical cadherin: Rat cadherin19 is expressed in the cranial ganglia and Schwann cell precursors during development. Dev Dyn. 2005 232(1) :200-108.

53) Nagase T, Nagase M, Osumi N, Fukuda S, Nakamura S, Ohsaki K, Harii K, Asato H, Yoshimura K. Craniofacial anomalies of the cultured mouse embryo induced by inhibition of sonic hedgehog signaling: an animal model of holoprosencephaly. J Craniofac Surg. 2005 Jan;16(1):80-8.

54) Yokoo T, Ohashi T, Shen JS, Sakurai K, Miyazaki Y, Utsunomiya Y, Takahashi M, Terada Y, Eto Y, Kawamura T, Osumi N, Hosoya T. Human mesenchymal stem cells in rodent whole-embryo culture are reprogrammed to contribute to kidney tissues. Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3296-300.

55) Fushimi K, Osumi N, Tsukahara T. NSSRs/TASRs/SRp38s function as splicing modulators via binding to pre-mRNAs. Genes Cells. 2005 Jun;10(6):531-41.

56) Kohwi, M., Osumi, N, Rubenstein, JLR, and Alvarez-Buylla, A. Pax6 is required for making specific subpopulations of granule and periglomerular neurons in the olfactory bulb. J Neurosci. 2005 Jul 27;25(30):6997-7003.

57) Maekawa, M., Takashima, N. Arai, Y., Nomura, T., Inokuchi, K., Yuasa, S. and Osumi, N.　Pax6 is required for production and maintenance of progenitorcells in postnatal hipocampal neurogenesis　Genes Cells. 10(10),1001-1014, 2005.

58) Tomita, Y., Matsumura, K., Wakamatsu, Y., Matsuzaki, Y., Shibuya, I.,Kawaguchi, H., Ieda, M., Kanakubo, S., Shimazaki, T., Ogawa, S., Osumi, N., Okano, H. and Fukuda, K. Cardiac neural crest cells as dormant multipotential stem cells in the mammalian heart. J Cell Biol. 2005 Sep 26;170(7):1135-46.

59) Sakai D, Tanaka Y, Endo Y, Osumi N, Okamoto H, Wakamatsu Y. Regulation of Slug transcription in embryonic ectoderm by beta-catenin-Lef/Tcf and BMP-Smad signaling. Dev Growth Differ. 2005 Sep;47(7):471-82.

60) Arai, Y., Funatsu, N., Numayama-Tsuruta, K., Nomura, T., Nakamura, S. and Osumi, N.　Role of Fabp7, a downstream gene of Pax6, in maintenance of neuroepithelialcells during early embryonic development of the rat cortex. J Neurosci. 2005 Oct 19;25(42):9752-61.

61) Ogawa,Y., Takebayashi, H., Takahashi, M., Osumi, N., Iwasaki, Y. and Ikenaka, K. Gliogenic radial glial cells show heterogeneity in the developing mouse spinal cord. Dev Neurosci. 2005;27(6):364-77.

62) Nomura,T.,Holmberg, J., Frisen, J. and Osumi, N. Pax6-dependent boundary defines alignment of migrating olfactory cortex neurons via the repulsive activity of ephrin-A5. Development. 2006 Apr;133(7):1335-45.

63) Sakai, D., Suzuki, T., Osumi, N., and Wakamatsu, Y. Cooperative action of Sox9, Snail2, and PKA signaling in early neural crest development. Development. 2006 Apr;133(7):1323-33.

64) Sachiko Kanakubo, Tadashi Nomura, Ken-ichi Yamamura, Jun-ichi Miyazaki, Makoto Tamai, Noriko Osumi. Abnormal migration and distribution of neural crest cells in Pax6 heterozygous mutant eye, a model for human eye diseases. Genes to Cells, 11, 919-933.

65) Shimizu H, Iwayama Y, Yamada K, Toyota T, Minabe Y, Nakamura K, Nakajima M, Hattori E, Mori N, Osumi N, Yoshikawa T. Genetic and expression analyses of the STOP (MAP6) gene in schizophrenia. Schizophr Res. 2006 Jun;84(2-3):244-52.

66) Nakatani N, Hattori E, Ohnishi T, Dean B, Iwayama Y, Matsumoto I, Kato T, Osumi N, Higuchi T, Niwa S, Yoshikawa T. Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: relevance to neuronal network perturbation. Hum Mol Genet. 2006 Jun 15;15(12):1949-62.

67) Suzuki T, Sakai D, Wada, H, Osumi N, Wakamatsu Y. Sox genes regulate type 2 collagen expression in avian neural crest cells. Develop. Growth Differ. 48, 477-486, 2006.

68) Depitri Tonelli D, Calegari F, Fei JF, Nomura T, Osumi N, Heisenberg CP, and Huttner WB. Single-cell detection of microRNAs in developing vertebrate embryos after acute admistration of a dual-fluorescence reporter/sensor plasmid. Biotechniques 41, 727-732, 2006

69) Sugiyama D, Ogawa M, Nakao K, Osumi N, Nishikawa S, Nishikawa S, Arai K, Nakahata T, Tsuji K.B cell potential can be obtained from pre-circulatory yolk sac, but with low frequency.Dev Biol. 301, 53-61, 2007 .

70) Ohnishi T, Yamada K, Ohba H, Iwayama Y, Toyota T, Hattori E, Inada T, Kunugi H, Tatsumi M, Ozaki N, Iwata N, Sakamoto K, Iijima Y, Iwata Y, Tsuchiya KJ, Sugihara G, Nanko, S, Osumi N, Detera-Wadkeiqh SD, Kato T, Yoshikawa T. Neuropsychopharmacology. Aug;32(8):1727-37, 2007

71) Jason E. Long, Sonia Garel, Manuel Alvarez-Dolado, Kazuaki Yoshikawa, Noriko Osumi, Arturo Alvarez-Buylla, and John L. R. RubensteinDlx-dependent and -independent regulation of olfactory bulb interneuron differentiation J. Neurosci. 27, 3230-3243, 2007

72) Wakamatsu, Y., Nakamura, N., Lee, J.A., Cole, G.J. and Osumi N. Transitin, a nestin-like intermediate filament protein, mediates cortical localization and the lateral transport of Numb in mitotic avian neuroepithelial cells. Development. 2007 Jul;134(13):2425-33.

73) Tamai, H., Shinohara, H., Miyata, T., Saito, K., Nishizawa, Y. Nomura, T. and Osumi, N. Pax6 transcription factor is required for the interkinetic nuclear movement of neuroepithelial cells. Genes Cells 12, 983-96, 2007.

74) Watanabe, A., Toyota, T., Owada, Y., Hayashi, T., Iwayama, Y., Matsumata, M., Ishitsuka, Y., Nakaya, A., Maekawa, M., Ohnishi, T., Arai, R., Sakurai, K., Yamada, K., Kondo, H., Hashimoto, K., Osumi, N. and Yoshikawa, T. PLoS Biol. 2007 Nov 13;5(11):e297.

75) Nomura, T. Takahashi, M, Hara, Y. and Osumi, N. Patterns of neurogenesis and amplitude of Reelin expression are essential for making a mammalian-type cortex. PLosOne, 3(1):e1454

76) Sakurai, K. and Osumi, N. The neurogenesis-controlling factor, Pax6, inhibits proliferation and promotes maturation in murine astrocytes. J.Neurosci. 28(18), 4604-4612.

77) Takahashi, M. and Osumi, N. Expression study of cadherin 7 and cadherin 20 in the embryonic and adult rat central nervous system. BMC. Dev. Biol. 8: 87, 2008
78) Meltrin beta/ADAM19 interacting with EphA4 in developing neural cells participates in formation of the neuromuscular junction.
Yumoto N, Wakatsuki S, Kurisaki T, Hara Y, Osumi N, Frisen J, Sehara-Fujisawa A.
PLoS ONE. 2008 Oct 2;3(10):e3322.

79) Competent stripes for diverse positions of limbs/fins in gnathostome embryos.
Yonei-Tamura S, Abe G, Tanaka Y, Anno H, Noro M, Ide H, Aono H, Kuraishi R, Osumi N, Kuratani S, Tamura K.
Evol Dev. 2008 Nov-Dec;10(6):737-45.

80) Development of the mouse amygdala as revealed by enhanced green fluorescent protein gene transfer by means of in utero electroporation.
Soma M, Aizawa H, Ito Y, Maekawa M, Osumi N, Nakahira E, Okamoto H, Tanaka K, Yuasa S.
J Comp Neurol. 2008 Dec 23;513(1):113-128. [Epub ahead of print]

　　■　Review

1) Osumi-Yamashita N., & Eto K.: Mammalian cranial neural crest cells and facial development. Develop. Growth Differ. 32, 451-459, 1990.

2) Eto, K., & Osumi-Yamashita N.: Whole embryo culture and the study of post-implantation mammalian development. Develop. Growth Differ. 37, 123-132, 1995.

3) Osumi-Yamashita N.: Retinoic acid and mammalian craniofacial morphogenesis. J. Biosci. 21, 313-327, 1996.

4) Osumi-Yamashita N., Ninomiya, Y., & Eto K.: Craniofacial embryology in vitro. Int. J. Devel. Biol. 41, 187-194, 1997.

5) Takahashi Y, Osumi N, Patel NH. Body patterning. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12338-9.

6) Inoue T, Nakamura S, Osumi N. Current topics in comparative developmental biology of vertebrate brains.
Neurosci Res. 2001 Apr;39(4):371-6.

7) Osumi N . The role of Pax6 in brain patterning. Tohoku J Exp Med. 193, 163-74, 2001.

8) Osumi N, Inoue T. Gene Transfer into Cultured Mammalian Embryos by Electroporation. Methods. 2001 May;24(1):35-42.

9) Takahashi, M., Sato, K., Nomura, T. and Osumi, N. Manipulating gene expressions by electroporation in the developing brain of mammalian embryos. Differentiation 2002 70:155-162.

10) Nomura, T., Haba, H. and Osumi, N. Role of a transcription factor Pax6 in the developing vertebrate olfactory system.Dev Growth Differ. 2007 Oct 30;49(9):683-690.

11) Osumi, N., Shinohara, H., Numayama-Tsuruta, K. and Maekawa, M.Pax6 Transcription Factor Contributes to Both Embryonic and Adult Neurogenesis as a Multifunctional Regulator.Stem Cells. 2008 May 8

12) Takahashi, M., Nomura, T. and Osumi, N. Transferring genes into cultured mammalian embryos by electroporation. Dev. Growth Differ. 2008 2008 Aug;50(6):485-97

　　■　Book

1) Osumi, N. and Nakafuku, M.: Pax-6 is involved in specification of ventral cell types in the hindbrain. In Neural Development: Keio Univ. Symposia for Life Science and Medicine: Vol. 2 K. Uyemura, K. Kawamura, T. Yazaki (Eds) pp.117-124, 1998, Springer-Verlag Tokyo.

2) Fukuzaki U and Osumi, The search for downstream target genes of Pax6 uing microarray analysis. Bionanotechnology Based Future Medical Engineering Proceedings of the Tohoku University 21st Century Center of Excellence Programme (Eds M Esashi, K Ishii, N Ohuchi, N Osumi, M Sato, T Yamaguchi),79-84, 2007

3) Knakubo S and Osumi, N. Developmental contribution of neural crest-derived cells in murine eye structure. Bionanotechnology Based Future Medical Engineering Proceedings of the Tohoku University 21st Century Center of Excellence Programme (Eds M Esashi, K Ishii, N Ohuchi, N Osumi, M Sato, T Yamaguchi),111-120, 2007

4) Maekawa M and Osumi, N. The role of Pax6 in postnatal hippocampal neurogenesisBionanotechnology Based Future Medical Engineering Proceedings of the Tohoku University 21st Century Center of Excellence Programme (Eds M Esashi, K Ishii, N Ohuchi, N Osumi, M Sato, T Yamaguchi),121-128, 2007

5) Nakamura N, Osumi, N and Wakamatsu Y. Time-lapse observation of neural epithelium cell behabior in slice culture. Bionanotechnology Based Future Medical Engineering Proceedings of the Tohoku University 21st Century Center of Excellence Programme (Eds M Esashi, K Ishii, N Ohuchi, N Osumi, M Sato, T Yamaguchi),145-150, 2007

6) Numayama-Tsuruta K, Arai Y and Osumi, N.The rat small eye homozygote (rSey2/rSey2) can be regarded as a Pax6 null mutant. Bionanotechnology Based Future Medical Engineering Proceedings of the Tohoku University 21st Century Center of Excellence Programme (Eds M Esashi, K Ishii, N Ohuchi, N Osumi, M Sato, T Yamaguchi),151-162, 2007

7) Sakurai K and Osumi, N. The role of Pax6 in postnatal hippcamcap neurogenesis in the mouse. Bionanotechnology Based Future Medical Engineering Proceedings of the Tohoku University 21st Century Center of Excellence Programme (Eds M Esashi, K Ishii, N Ohuchi, N Osumi, M Sato, T Yamaguchi),183-188, 2007

8) Sazuki T, Sakai D, OSumi N and Wakamatsu Y. Expression of Sox9-interacting protein SC35/sfrs2 in avian embryos. Bionanotechnology Based Future Medical Engineering Proceedings of the Tohoku University 21st Century Center of Excellence Programme (Eds M Esashi, K Ishii, N Ohuchi, N Osumi, M Sato, T Yamaguchi),199-202, 2007

9) Tsunekawa Y, Takahashi M and Osumi, N. Labeling of neuroepithelial cells using whole embryo culture and gene transfer methods to characterize the cell cycle. Bionanotechnology Based Future Medical Engineering Proceedings of the Tohoku University 21st Century Center of Excellence Programme (Eds M Esashi, K Ishii, N Ohuchi, N Osumi, M Sato, T Yamaguchi),203-210, 2007

10) Takahashi M and Osumi, N. LIve imaging of neuroepithelial cells in the rat spinal cord by confocal laser-scaninig microscopy. Bionanotechnology Based Future Medical Engineering Proceedings of the Tohoku University 21st Century Center of Excellence Programme (Eds M Esashi, K Ishii, N Ohuchi, N Osumi, M Sato, T Yamaguchi), 211-220, 2007

　　■　Abstract

1) Osumi N. Woman scientists in Japan: their situation and goals. IUBMB Life, 58, 273-278, 2006


▲page top▲