Recent-publications
- Naher S., Iemura K., Miyashita S., Hoshino M., Tanaka K., Niwa S., Tsai JW., Kikkawa T &Osumi N.:Kinesin-like motor protein KIF23 maintains neural stem and progenitor cell pools in the developing cortex. The EMBO Journal.(December 2024)
https://doi.org/10.1038/s44318-024-00327-7 - Germeraad J., Kikkawa T., Osumi N.: Vitamin E supplementation prevents ferroptosis in round spermatids
of aged mice. bioRxiv. (October 2024)
https://www.biorxiv.org/content/10.1101/2024.10.21.619554v1 - Corales LG., Inada H., Owada Y., Osumi N.: Fatty acid preference for beta-oxidation in mitochondria of murine cultured astrocytes. Genes Cells. (September 2024) https://onlinelibrary.wiley.com/doi/10.1111/gtc.13144
- Ochi S.,Manabe S.,Kikkawa T., Ebrahimiazar S.,Kimura R.,Yoshizaki K.,&Osumi N.: A Transcriptomic Dataset of Embryonic Murine Telencephalon. Scientific Data. (June 2024) https://www.nature.com/articles/s41597-024-03421-x
- Kanlayaprasit S., Saeliw T., Thongkorn S., Panjabud P., Kasitipradit K., Lertpeerapan P., Songsritaya K., Yuwattana W., Jantheang T., Jindatip D., Hu VW., Kikkawa T., Osumi N., Sarachana T.: Sex-specific impacts of prenatal bisphenol A exposure on genes associated with cortical development, social behaviors, and autism in the offspring's prefrontal cortex. Biol Sex Differ. (May 2024) https://bsd.biomedcentral.com/articles/10.1186/s13293-024-00614-2
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Miyahara K., Tatehana M., Kikkawa T.,Osumi N*.,：Investigating the impact of paternal aging on murine sperm miRNA profiles and their potential link to autism spectrum disorder. Scientific Reports.(December 2023)
https://www.nature.com/articles/s41598-023-47878-z【Press Release】
Tohoku University Press Release (2023.12.8)
https://www.tohoku.ac.jp/japanese/2023/12/press20231208-01-rna.html -
Mai L.,Inada H.,Osumi N.,:Whole-brain mapping of neuronal activity evoked by maternal separation in neonatal mice: An association with ultrasound vocalization.Neuropsychopharmacology Reports.(May 2023)
https://onlinelibrary.wiley.com/doi/full/10.1002/npr2.12337 - Shinohara, M,K., Honda, N., Tanaka,T.,Tatehana, M., Kikkawa,T., Osumi, N., Shinohara,T.:Regulation of male germline transmission patterns by the Trp53-Cdkn1a pathway. Stem Cell Reports (2022).
doi:10.1016/j.stemcr.2022.07.007 - .Nagai,M., Iemura,K., Kikkawa,T., Naher,S., Hattori,S., Hagihara, H., Nagata,K., Anzawa,H., Kugisaki,R., Wanibuchi,H., et al：Deficiency of CHAMP1, a gene related to intellectual disability, causes impaired neuronal development and a mild behavioral phenotype. Brain Communications 30 August.
doi:10.1093/braincomms/fcac220【Press Release】
Tohoku University Press Release (2022.8.10)
https://www.tohoku.ac.jp/en/press/Role_of_champ1_gene_in_neuronal_development.html - Mai, L., Inada, H., Kimura, R., Kanno, K., Matsuda,T., Tachibana, R O.,
Tucci,V., Komaki ,F., Hiroi, N., Osum, N.：Advanced paternal age diversifies individual trajectories of vocalization patterns in neonatal mice. iScience (2022).
doi:10.1016/j.isci.2022.104834【Press Release】
Tohoku University Press Release (2022.8.10) - Corales, L G., Inada, H., Hiraoka, K., Araki, S., Yamanaka, S., Kikkawa, T., Osumi, N.:The subcommissural organ maintains features of neuroepithelial cells in the adult mouse. Journal of Anatomy.31 May 2022.
doi:10.1093/braincomms/fcac220 - Ochi, S., Manabe, S., Kikkawa, T., Osumi, N. :Thirty Years’ History since the Discovery of Pax6: From Central Nervous System Development to Neurodevelopmental Disorders. Int. J. Mol. Sci. 2022, 23(11), 6115.
doi:10.3390/ijms23116115 - Kikkawa, T., Osumi, N.: Multiple functions of the Dmrt genes in the development of the central nervous system. Front Neurosci, 2021. Front. Neurosci., 09 December 2021.
doi:10.3389/fnins.2021.789583 - Kanlayaprasit, K., Thongkorn, S., Panjabud, P., Jindatip, D., Hu, VW., Kikkawa, T., Osumi, N., Sarachana, T.: Autism-Related Transcription Factors Underlying the Sex-Specific Effects of Prenatal Bisphenol A Exposure on Transcriptome-Interactome Profiles in the Offspring Prefrontal Cortex. Int J Mol Sci, 2021. 22(24) .
doi:10.3390/ijms222413201 - Maximiliano José Nigro, Hinako Kirikae, Kasper Kjelsberg, Rajeevkumar Raveendran Nair and Menno P. Witter.: Not All That Is Gold Glitters:PV-IRES-Cre Mouse Line Shows Low Efficiency of Labeling of Parvalbumin Interneurons in the Perirhinal Cortex. Front. Neural Circuits, 08 November 2021.
doi: 10.3389/fncir.2021.781928 - *Kimura R, *Yukiko U. Inoue, *Kikkawa T, et al.: Detection of REST expression in the testis using epitope-tag knock-in mice generated by genome editing. Dev Dyn 2021. doi: 10.1002/dvdy.417. Online ahead of print
(*equally contributed)
doi:10.1002/dvdy.417. - Osumi, N., Tatehana, M.: Transgenerational epigenetic information through the sperm: Sperm cells not just merely supply half of the genome for new life; they also seem to transmit additional information via epigenetic modifications. EMBO Rep.2021 Aug 4;22(8):e53539.
doi:10.15252/embr.202153539. - Ichijo, S., Shindo, T., Eguchi, K., Monma, Y., Nakata, T., Morisue, Y., Kanai, H., Osumi, N., Yasuda, S., Shimokawa, H.: Low-intensity pulsed ultrasound therapy promotes recovery from stroke by enhancing angio-neurogenesis in mice in vivo. Sci Rep. 2021 Mar 2;11(1):4958.
doi: 10.1038/s41598-021-84473-6.【Press Release】
Tohoku University Press Release (2021.3.3) - Thongkorn, S., Kanlayaprasit, S., Panjabud, P., Saeliw, T., Jantheang, T., Kasitipradit, K., Sarobol, S., Jindatip, D., Hu, VW., Tencomnao, T., Kikkawa, T., Sato, T., Osumi, N., Sarachana, T.: Sex differences in the effects of prenatal bisphenol A exposure on autism-related genes and their relationships with the hippocampus functions. Sci Rep. 11(1):1241, 2021. doi: 10.1038/s41598-020-80390-2.
【Press Release】
Tohoku University Press Release (2021.1.19)“Prenatal BPA Exposure May Contribute to the Male Bias of Autism Spectrum Disorder” - Yoshizaki, K., Kimura, R., Kobayashi, H., Oki, S., Kikkawa, T., Mai, L., Koike, K., Mochizuki, K., Inada, H., Matsui, Y., Kono, T., Osumi, N.: Paternal age affects offspring via an epigenetic mechanism involving REST/NRSF.EMBO Rep. 2021. e51524. doi: 10.15252/embr.202051524. 2021 Jan 5: Online ahead of print.
【Press Release】
Tohoku University Press Release (2021.1.5)“Age of Father Affects Offspring Through an Epigenetic Mechanism” - Casingal, C.R., Kikkawa, T., Inada, H., Sasaki, Y., Osumi, N.: Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/β-catenin, and mTOR signaling during corticogenesis.Mol Brain 13(1):167, 2020. doi: 10.1186/s13041-020-00706-1.
【Press Release】
Tohoku University Press Release (2020.12.16)“New Insights into Fragile X Syndrome and the Fetal Brain” - Kikkawa, T., Casingal, C, R., Chun, S, H., Shinohara, H., Hiraoka, K. and Osumi, N.: The role of Pax6 in brain development and its impact on pathogenesis of autism spectrum disorder. Brain Research. 1705, 95-103, 2019.
- Mochizuki, K., Hayashi, Y., Sekinaka, T., Otsuka, K., Ito-Matsuoka, Y., Kobayashi, H., Oki, S., Takehara, A., Kono, T., Osumi, N. and Matsui, Y.: Repression of Somatic Genes by Selective Recruitment of HDAC3 by BLIMP1 Is Essential for Mouse Primordial Germ Cell Fate Determination. Cell Reports. 24(10), 2682-2693.e6, 2018.
- Eguchi, K., Shindo, T., Ito, K., Ogata, T., Kurosawa, R., Kagaya, Y., Monma, Y., Ichijo, S., Kasukabe, S., Miyata, S., Yoshikawa, T., Yanai, K., Taki, H., Kanai, H., Osumi, N., Shimokawa, H.: Whole-brain low-intensity pulsed ultrasound therapy markedly improves cognitive dysfunctions in mouse models of dementia - Crucial roles of endothelial nitric oxide synthase. Brain Stimulation. 11(5), 959-973, 2018.
- Kimura, R., Yoshizaki, K., Osumi, N.: Risk of Neurodevelopmental Disease by Paternal Aging: A Possible Influence of Epigenetic Alteration in Sperm. Developmental Origins of Health and Disease (DOHaD). Advances in Experimental Medicine and Biology. 1012, 75-81, 2018.
- Maekawa, M., Watanabe, A., Iwayama, Y., Kimura, T., Hamazaki, K., Balan, S., Ohba, H., Hisano, Y., Nozaki, Y., Ohnishi, T., Toyoshima, M., Shimamoto, C., Iwamoto, K., Bundo, M., Osumi, N., Takahashi, E., Takashima, A., Yoshikawa T.
Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes. Transl Psychiatry. 7(9), e1229, 2017. - Nagasaki, M., Yasuda, J., Katsuoka, F., Nariai, N., Kojima, K., Kawai, Y., Yamaguchi-Kabata, Y., Yokozawa, J., Danjoh, I., Saito, S., Sato, Y., Mimori, T., Tsuda, K., Saito, R., Pan, X., Nishikawa, S., Ito, S., Kuroki, Y., Tanabe, O., Fuse, N., Kuriyama, S., Kiyomoto, H., Hozawa, A., Minegishi, N., Douglas Engel, J., Kinoshita, K., Kure, S., Yaegashi, N.; ToMMo Japanese Reference Panel Project, Yamamoto, M. Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals. Nat Commun. 6, 8018, 2015.
- Tsunekawa, Y., Britto, J.M., Takahashi, M., Polleux, F., Tan, S-S. and Osumi, N.: Cyclin D2 in the basal process of neural progenitors is linked to non-equivalent cell fates. EMBO J. 31(8), 1879-1892, 2012.
