We focus molecular and cellular mechanism of postnatal and adult neurogenesis
in the rat and mouse brains.
Neurogenesis in the postnal and adult hippocampus
Gliogenesis in the cerebral cortex
Behavior analysis of Pax6 hetrozygous mutant
Differentiation of interneurons in the olfactory bulb
Neurogenesis in the postnal hippocampus
Pax6 is involved in many aspects of the brain development including
neurogenesis. Expression of Pax6 is also observed in distinct regions of the
adult brain, such as the dentate gyrus of the hippocampus and the subventricular
zone neighboring the anterior lateral ventricle; both are known as regions where
adult neurogenesis takes place. In order to understand Pax6 function as a
driving force for neurogenesis in the adult stages, we are investigating
hippocampal neurogenesis of Pax6 mutant rats, which lacks one allele of
Pax6 gene (Tohoku
J Exp Med. 193, 163-74.; Maekawa et al., 2005)。

【Fig.1】Distribution of Pax6-positive cells in the adult rat hyppocampus
Pax6 is expressed in the progenitor like cells in the SGZ.

【Fig.2】Analysis of neurogenesis in the Pax6 heterozygous rat hyppocampus
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